C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 257/04 (2006.01) A61K 31/13 (2006.01) A61K 31/275 (2006.01) A61K 31/38 (2006.01) A61K 31/41 (2006.01) A61K 31/44 (2006.01) A61K 31/495 (2006.01) C07C 43/196 (2006.01) C07C 69/757 (2006.01) C07C 217/52 (2006.01) C07C 229/48 (2006.01) C07C 233/23 (2006.01) C07C 233/81 (2006.01) C07C 235/40 (2006.01) C07C 237/06 (2006.01) C07C 255/59 (2006.01) C07C 271/24 (2006.01) C07C 275/26 (2006.01) C07D 207/26 (2006.01) C07D 233/70 (2006.01) C07D 249/08 (2006.01) C07D 261/08 (2006.01) C07D 271/10 (2006.01) C07D 277/3
Patent
CA 2234913
The present invention is directed to certain novel compounds represented by structural formula (I) or a pharmaceutically acceptable salt thereof, wherein R3, R6, R7, R8, R11, R12, R13, A, Q, W, X, Y, Z and n are defined herein. The invention is also concerned with pharmaceutical formulations comprising these novel compounds as active ingredients and the use of the novel compounds and their formulation in the treatment of certain disorders. The compounds of this invention are tachykinin receptor antagonists and are useful in the treatment of inflammatory diseases, pain or migraine, asthma and emesis.
L'invention concerne de nouveaux composés représentés par la formule développée (I) ou leurs sels pharmaceutiquement acceptables. Dans ladite formule, R?3¿, R?6¿, R?7¿, R?8¿, R?11¿, R?12¿, R?13¿, A, Q, W, X, Y, Z et n correspondent à la définition donnée dans la description. L'invention concerne également des formulations pharmaceutiques comportant comme ingrédients actifs ces composés, ainsi que l'utilisation de ces composés et de leurs formulations dans le traitement de certains troubles. Les composés selon l'invention sont des antagonistes des récepteurs des tachykinines et sont utiles dans le traitement des maladies inflammatoires, des douleurs et des migraines, de l'asthme et des vomissements.
Caldwell Charles G.
Chen Ping
Durette Philippe L.
Finke Paul E.
Hale Jeffrey
Merck & Co. Inc.
Ogilvy Renault
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