Cyclosporin-containing powder composition

Details Cyclosporin-containing powder composition Cyclosporin-containing powder composition

A - Human Necessities

61

K

A61K 38/13 (2006.01) A61K 9/14 (2006.01) A61K 9/16 (2006.01) A61K 9/48 (2006.01)

Patent

CA 2161343

The present invention relates to a cyclosporin-containing powder composition which comprises cyclosporin, a non-ionic hydrophilic surfactant and a porous carrier. In addition, the present invention relates to a method for preparing the cyclosporin-containing powder composition which comprises dissolving cyclosporin and a non-ionic hydrophilic surfactant in an organic solvent, adding a porous carrier to the resulting solution and then evaporating the organic solvent from the mixture. The powder composition of the present invention is stable and does not require a special manufacturing technique when it is formulated. In addition, since the powder composition of the present invention does not contain an organic solvent, the necessity of a special package is excluded. Furthermore, the composition of the present invention provides an improved bioavailability which results in decrease of a single dosage, and therefore, can contribute to the alleviation of the side effects associated with cyclosporin.

Composition pulvérulente renfermant de la cyclosporine, un tensioactif hydrophile non ionique et un véhicule poreux. On a également prévu un procédé de préparation de ladite composition pulvérulente renfermant de la cyclosporine, consistant à dissoudre la cyclosporine et un tensioactif hydrophile non ionique dans un solvant organique, à ajouter à la solution ainsi obtenue un véhicule poreux, et à évaporer le solvant organique à partir du mélange. Ladite composition pulvérulente est stable, et aucune technique spéciale de fabrication n'est nécessaire à sa formulation. En outre, étant donné que cette composition pulvérulente ne contient aucun solvant organique, tout conditionnement spécial est superflu. Par ailleurs, ladite composition offre une biodisponibilité améliorée entraînant une réduction de la posologie simple, et peut, de ce fait, contribuer à atténuer les effets secondaires associés à la cyclosporine.

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