C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/715 (2006.01) A61K 31/00 (2006.01) A61K 31/325 (2006.01) A61K 31/472 (2006.01) A61K 38/17 (2006.01) A61P 17/00 (2006.01) A61P 19/02 (2006.01) A61P 19/10 (2006.01) A61P 31/18 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) G06N 3/00 (2006.01)
Patent
CA 2460151
A crystalline composition comprising a crystal of the IL-6 receptor I chain is provided. Also provided are methods of using the crystal and related structural information to screen for and design compounds that interact with IL-6R, or variants thereof. Also provided are methods of modulating an IL-6 receptor comprising contacting the IL-6 receptor with a compound identified by the screening method of the invention.
L'invention concerne une composition cristalline comprenant un cristal de la chaîne .alpha. du récepteur d'IL-6. L'invention concerne également des procédés d'utilisation dudit cristal et d'informations structurelles pertinentes pour sélectionner et concevoir des composés qui entrent en interaction avec l'IL-6R ou des variantes desdits composés. L'invention concerne en outre des procédés permettant de moduler le récepteur d'IL-6, qui comprennent la mise en contact du récepteur d'IL-6 avec un composé identifié par le procédé de sélection de l'invention.
Branson Kim Matthew
Ji Hong
Lou Meizhen
Moritz Robert Lorenz
Simpson Richard J.
Commonwealth Scientific And Industrial Research Organisation
Ludwig Institute For Cancer Research
Smart & Biggar
Walter And Eliza Hall Institute Of Medical Research
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