Cytotoxic peptides

Details Cytotoxic peptides Cytotoxic peptides

C - Chemistry, Metallurgy

07

K

C07K 14/16 (2006.01) A61K 38/00 (2006.01) A61K 38/05 (2006.01) A61K 38/06 (2006.01) A61K 38/07 (2006.01) A61K 38/16 (2006.01) A61K 45/00 (2006.01) A61P 31/18 (2006.01) A61P 43/00 (2006.01) C07K 5/072 (2006.01) C07K 5/087 (2006.01) C07K 5/103 (2006.01) C07K 7/06 (2006.01) C12N 15/09 (2006.01) C12Q 1/02 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2263134

This invention relates to cytotoxic, myristylated peptides derived from the N- terminus of the Nef protein. The peptides preferably comprise a domain comprising a net positive charge and an .alpha.-helical region. The invention also relates to compounds which inhibit the cytotoxicity of the Nef protein, the methods of preventing Nef toxicity, HIV infection, and to pharmaceutical compositions comprising such compounds.

La présente invention concerne des peptides cytotoxiques myristilés dérivés de la terminaison N de la protéine Nef. Ces peptides comprennent de préférence un domaine comportant une charge positive nette et une région d'hélice .alpha.. L'invention, qui concerne également des composés inhibiteurs de la cytotoxicité par la protéine Nef, des techniques de prévention de la toxicité par la Nef, de prévention de l'infection par le VIH, concerne enfin des compositions pharmaceutiques comprenant de tels composés.

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