C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 313/00 (2006.01) A61K 31/365 (2006.01)
Patent
CA 2622912
The present invention concerns groups of compounds derived from tunicates of the Synoicum species, as well as to pharmaceutical compositions comprising these compounds, and uses thereof. Extracts from tunicates show selective toxicity against several different cancer cell lines in the NCI 60 cell line panel. These compounds are useful in the effective treatment of cancers, particularly malignant melanomas, colon cancer, and renal cancer cell lines.
La présente invention concerne des groupes de composés tirés de tuniqués de l'espèce Synoicum, ainsi que des compositions pharmaceutiques comprenant ces composés, et leurs utilisations. Des extraits de tuniqués font preuve d'une toxicité sélective contre différentes lignées de cellules cancéreuses du panneau des lignées cellulaires NCI 60. Ces composés conviennent au traitement de cancers, et notamment de mélanomes malins, du cancer du colon, et des lignées cellulaires cancéreuses du rein.
Amsler Charles D.
Baker Bill
Diyabalanage Thushara
Mcclintock James B.
Mbm Intellectual Property Law Llp
Uab Research Foundation
University Of South Florida
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