Dbait and uses thereof

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/11 (2006.01) A61K 31/713 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07H 21/00 (2006.01)

Patent

CA 2662065

The invention relates to compositions and methods for interfering with the DNA repair of double strand breaks (DSBs). The invention discloses novel double-stranded nucleic acid molecules that act as baits and hijack the holocomplex of enzymes responsible of DNA DSB sensing, signaling and/or repair pathways, in particular the non homologous end joining (NHEJ) pathway of DSB repair. The invention discloses the use of these molecules as adjuvant compositions to be used in association with a DNA breaking treatment, particularly radiotherapy or chemotherapy, in combination with a pharmaceutically acceptable carrier, in an efficient amount to be introduced in the tumor cell nuclei in order to neutralize transiently their DNA repair capacity and trigger their death.

L'invention concerne des compositions et des procédés pour interférer avec la réparation de l'ADN de cassures de double brin (DSB). L'invention concerne de nouvelles molécules d'acide nucléique double brin qui agissent en tant qu'appâts et détournent l'holocomplexe d'enzymes responsables des voies de détection, de signalisation et/ou de réparation des DSB de l'ADN, en particulier de la voie de liaison d'extrémité non homologue (NHEJ) de la réparation de DSB. L'invention concerne l'utilisation de ces molécules en tant que compositions adjuvantes devant être utilisées en association avec un traitement par cassure de l'ADN, en particulier une radiothérapie ou une chimiothérapie, en combinaison avec un support pharmaceutique acceptable, en une quantité efficace devant être introduite dans les noyaux des cellules tumorales afin de neutraliser de façon transitoire leur capacité de réparation de l'ADN et de déclencher leur mort.

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