Deacetylase inhibitors and uses thereof

Details Deacetylase inhibitors and uses thereof Deacetylase inhibitors and uses thereof

C - Chemistry, Metallurgy

07

C

C07C 251/86 (2006.01) A61K 31/15 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2731730

The present invention provides novel compounds of formula (I) and pharmaceutical compositions thereof. The inventive compounds are useful as deacetylase inhibitors (e.g., histone deacetylase inhibitors) and may be useful in the treatment of proliferative diseases such as cancer. In particular, the inventive compounds are HDAC6 inhibitors. The invention also provide synthetic methods for preparing the inventive compounds.

La présente invention porte sur de nouveaux composés représentés par la formule (I) et sur des compositions pharmaceutiques de ceux-ci. Les composés de l'invention sont utiles en tant quinhibiteurs de désacétylase (par exemple en tant quinhibiteurs d'histone désacétylase) et peuvent être utiles pour le traitement de maladies prolifératives telles qu'un cancer. En particulier, les composés de l'invention sont des inhibiteurs de HDAC6. L'invention porte également sur des procédés de synthèse pour la fabrication des composés de l'invention.

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