Death domain containing receptor 4

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/715 (2006.01) A61K 38/19 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07K 14/705 (2006.01) C07K 19/00 (2006.01) A61K 38/00 (2006.01) C07K 16/28 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2373063

The present invention relates to novel Death Domain Containing Receptor-4 (DR4) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR4 proteins. DR4 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR4 activity and methods for using DR4 polynucleotides and polypeptides.

La présente invention porte sur de nouvelles protéines du récepteur 4 (DR4) contenant le domaine de la mort cellulaire programmée et qui sont des éléments de la famille du récepteur du facteur de nécrose tumorale (TNF). L'invention porte notamment sur des molécules d'acide nucléique isolées codant les protéines humaines de DR4. L'invention porte également sur des polypeptides de DR4, ainsi que sur des vecteurs, des cellules hôtes et sur des procédés de recombinaison visant à produire ces polypeptides. L'invention porte en outre sur des procédés de criblage visant à identifier des agonistes et des antagonistes de l'activité de DR4 et sur des procédés d'utilisation des polynucléotides et polypeptides de DR4.

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