Degradable clostridial toxins

Details Degradable clostridial toxins Degradable clostridial toxins

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) C07K 14/33 (2006.01) C07K 19/00 (2006.01) C07K 14/705 (2006.01) C12N 9/52 (2006.01) C12N 15/57 (2006.01)

Patent

CA 2578911

The specification discloses modified Clostridial toxins comprising a PAR ligand domain, a Clostridial toxin enzymatic domain, a Clostridial toxin translocation domain and a Clostridial toxin binding domain; polynucleotide molecules encoding modified Clostridial toxins comprising a PAR ligand domain, a Clostridial toxin enzymatic domain, a Clostridial toxin translocation domain and a Clostridial toxin binding domain; and method of producing modified Clostridial toxins comprising a PAR ligand domain, a Clostridial toxin enzymatic domain, a Clostridial toxin translocation domain and a Clostridial toxin binding domain.

Cette invention concerne des toxines clostridiales modifiées comprenant un domaine de ligand PAR, un domaine enzymatique pour toxines clostridiales, un domaine de translocation pour toxines clostridiales et un domaine de liaison pour toxines clostridiales; des molécules de polynucléotides codant pour les toxines clostridiales modifiées susmentionnées; et un procédé de fabrication pour toxines clostridiales modifiées susmentionnées.

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