Dehydrated liposomes

Details Dehydrated liposomes Dehydrated liposomes

A - Human Necessities

61

K

167/162

A61K 9/60 (2006.01) A61K 9/127 (2006.01) A61K 9/52 (2006.01) A61K 39/00 (2006.01) A61K 47/48 (2006.01)

Patent

CA 1294548

ABSTRACT A method for loading liposomes with a charged material comprises the steps of: a) preparing a liposome preparation which includes liposomes having a concentration gradient of one or more charged species across their membranes, the concentration gradient being capable of generating a transmembrane potential having an orientation which will load the charged material into the liposomes; b) dehydrating the liposome preparation; c) storing the dehydrated preparation; d) rehydrating the dehydrated preparation; and e) admixing the charged material with the rehydrated preparation. The liposomes may also contain a protective sugar. The liposomes are useful in that they can be loaded with drugs to provide pharmaceutical preparations.

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