Delivery of opioids through an inhalation route

Details Delivery of opioids through an inhalation route Delivery of opioids through an inhalation route

A - Human Necessities

61

K

A61K 31/485 (2006.01) A61K 9/72 (2006.01) A61K 31/135 (2006.01) A61K 31/4468 (2006.01) A61K 31/4535 (2006.01)

Patent

CA 2446916

The present invention relates to the delivery of opioids through an inhalation route. Specifically, it relates to aerosols containing opioids that are used in inhalation therapy. In a composition aspect of the present invention, the aerosol comprises particles comprising at least 5 percent by weight of an opioid. In a method aspect of the present invention, an opioid is delivered to a mammal through an inhalation route. The method comprises: a) heating a composition, wherein the composition comprises at least 5 percent by weight of an opioid, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles, which is inhaled by the mammal. In a kit aspect of the present invention, a kit for delivering an opioid through an inhalation route to a mammal is provided which comprises: a) a composition comprising at least 5 percent by weight of an opioid; and, b) a device that forms an opioid aerosol from the composition, for inhalation by the mammal.

L'invention concerne l'administration d'opioïdes par voie inhalée. En particulier, l'invention concerne des aérosols contenant des opioïdes utilisés dans une thérapie d'inhalation. Dans un aspect de la composition de l'invention, l'aérosol comprend des particules comprenant au moins 5 % en poids d'un opioïde. Dans un aspect du procédé d'invention, un opioïde est administré à un mammifère par voie inhalée. Le procédé consiste à: (a) chauffer une composition, ladite composition comprenant au moins 5 % en poids d'un opioïde pour former une vapeur; et, (b) permettre à la vapeur de refroidir, pour former un aérosol par condensation comprenant des particules, lesquelles sont inhalées par ledit mammifère. Dans un aspect d'une trousse de diagnostic de l'invention, une trousse de diagnostic est destinée à libérer un opioïde par voie inhalée à un mammifère, comprenant: (a) une composition comprenant au moins 5 % en poids d'un opioïde; et, (b) un dispositif formant un aérosol d'opioïde à partir de ladite composition, à inhaler par ledit mammifère.

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