Derivatives of 1,2,3,4-tetrahydro-9-acridinamine

Details Derivatives of 1,2,3,4-tetrahydro-9-acridinamine Derivatives of 1,2,3,4-tetrahydro-9-acridinamine

C - Chemistry, Metallurgy

07

D

167/227, 260/282

C07D 219/10 (2006.01) A61K 31/435 (2006.01)

Patent

CA 2022297

Novel prodrugs or depot derivatives of 1,2,3,4-tetra-hydro-9- acridinamine are described, as well as methods for the preparation and pharmaceutical compositions of same, which are useful as analgesic agents for the treatment of pain, as sleep aids and as agents for treating the symptoms of senile dementia, Alzheimer"s disease, Huntington"s chorea, tardive dyskinesia, hyperkinesia, mania, or similar conditions of cerebral insufficiency characterized by decreased cerebral acetylcholine production or release. Embodiments of the invention have the following general structural formula: Image wherein X is O or CH2; and R is alkyl of from one to twenty carbon atoms, or Image wherein n is zero or an integer of one to twenty.

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