Derivatives of 4- (cycloalkyl) piperidines and of 4-...

C - Chemistry – Metallurgy – 07 – D

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C07D 211/14 (2006.01) A61K 31/445 (2006.01) A61K 31/47 (2006.01) A61K 31/55 (2006.01) C07D 211/12 (2006.01) C07D 401/06 (2006.01)

Patent

CA 2231326

Compounds of general formula (I) are described, wherein Ar is (a) a phenyl group substituted with a halogen atom or (b) a group of general formula (I'), wherein X is a group of formula -CH2-, -(CH2)2- or -(CH2)3- and Z is a hydrogen or halogen atom or a methyl group, Y is a group of formula -CH2-, -CO- or -CHOH-, R1 is a hydrogen atom or a methyl group, R2 is a C3-C7 cycloalkyl group, and n is 0, 1, 2 or 3. Said compounds are useful in therapeutical applications as neurotrophic and neuroprotective agents.

Composés répondant à la formule générale (I), dans laquelle Ar représente (a) un groupe phényle substitué par un atome d'halogène ou bien (b) un groupe de formule générale (I'), dans laquelle X représente un groupe de formule -CH¿2?-, -(CH¿2?)¿2?- ou -(CH¿2?)¿3?- et Z représente un atome d'hydrogène ou d'halogène ou un groupe méthyle, Y représente un groupe de formule -CH¿2?-, -CO- ou -CHOH-, R¿1? représente un atome d'hydrogène ou un groupe méthyle, R¿2? représente un groupe cycloalkyle en C¿3?-C¿7?, et n représente le nombre 0, 1, 2 ou 3. Application en thérapeutique comme agents neurotrophes et neuroprotecteurs.

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