Derivatives of 4-or 5-aminosalicylic acid

C - Chemistry – Metallurgy – 07 – F

Patent

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Details

C07F 9/6578 (2006.01) A61K 31/16 (2006.01) A61K 31/255 (2006.01) A61K 31/27 (2006.01) A61K 31/325 (2006.01) C07C 321/14 (2006.01) C07C 327/40 (2006.01) C07C 333/02 (2006.01) C07D 339/04 (2006.01)

Patent

CA 2609224

The present invention provides new derivatives of 4-or 5-aminosalicylic acid, and a pharmaceutical composition containing these derivatives of 4-or 5- aminosalicylic acid as active ingredients, useful for the treatment of intestinal diseases such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) and for the prevention/treatment of colon cancer. More particularly, these derivatives comprise a hydrogen sulfide releasing moiety linked via an azo, an ester, an anhydride, a thioester or an amide linkage to a molecule of 4-or 5-aminosalicylic acid. Furthermore, the present invention provides a process for preparing these compounds and their use for treating IBD and IBS and the prevention/treatment of colon cancer.

La présente invention concerne de nouveaux dérivés d'acide 4- ou 5-aminosalicylique, ainsi qu'une composition pharmaceutique contenant ces dérivés d'acide 4- ou 5-aminosalicylique comme ingrédients actifs, qui est utilisée pour traiter des maladies intestinales comme une maladie inflammatoire de l'intestin (inflammatory bowel disease: IBD) et le syndrome du côlon irritable (irritable bowel syndrome: IBS) et pour prévenir/traiter un cancer du côlon. Ces dérivés comprennent en particulier un groupe de libération de sulfure d'hydrogène qui est lié via une liaison azo, ester, anhydride, thioester ou amide à une molécule d'acide 4- ou 5-aminosalicylique. Cette invention concerne également un procédé pour préparer ces composés, ainsi que leur utilisation pour traiter une maladie inflammatoire de l'intestin et le syndrome du côlon irritable et pour prévenir/traiter un cancer du côlon.

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