Derivatives of 6-(6-o-cycloalkyl or...

C - Chemistry – Metallurgy – 07 – D

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Details

C07D 277/82 (2006.01) A61K 31/5025 (2006.01) A61P 35/00 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2751525

The invention relates to novel products of the formula (I) where: - - - - is a single or double bond; Ra is -O-cycloalkyl or -NH-cycloalkyl; X is S, SO or SO2, A is NH or S; W is H, alkyl or COR with R being cycloalkyl; alkyl; alkoxy; O-phenyl; -O-(CH2)n-phenyl with n = 1 to 4; or NR1R2 with R1 is H or alk and R2 is H, cycloalkyl, heterocycloalkyl, or alkyl; or R1, R2 form a cycle with N optionally containing O, S, N and/or NH; wherein all of said radicals are optionally substituted; and wherein said products are in any isomer or salt form and can be used as drugs, in particular as MET inhibitors.

L'invention concerne les nouveaux produits de formule (I) dans laquelle .... représente une liaison simple ou double; Ra représente -O-cycloalkyle ou -NH-cycloalkyle; X représente S, SO ou SO2, A représente NH ou S; W représente H, alkyle ou COR avec R représente cycloalkyle; alkyle; alcoxy; O-phényle; -O- (CH2)n-phényle avec n= 1 à 4; ou NR1R2 avec R1 représente H ou alk et R2 représente H, cycloalkyle, hétérocycloalkyle, ou alkyle; ou bien R1, R2 forment avec N un cycle renfermant éventuellement O, S, N et/ou NH; tous ces radicaux étant éventuellement substitués; ces produits étant sous toutes les formes isomères et les sels, à titre de médicaments notamment comme inhibiteurs de MET.

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