Derivatives of a-21978c cyclic peptides and their production

Details Derivatives of a-21978c cyclic peptides and their production Derivatives of a-21978c cyclic peptides and their production

C - Chemistry, Metallurgy

07

K

530/7.08

C07K 7/64 (2006.01) C07K 7/08 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1215043

Abstract of the Invention A-21978C cyclic peptide derivatives of the formula Image wherein R is a substituted benzoyl group of the formula Image in which R2 is C8-C15 alkyl; X is hydrogen, chloro, bromo iodo, nitro, C1-C3 alkyl, hydroxy, C1-C3 alkoxy, or C1-C3 alkylthio; and R1 is hydrogen or an amino-protecting group; and the salts thereof, are useful new semi- synthetic antibiotic agents or intermediates to such agents. These new agents can be prepared by reacting the A-21978C nucleus, prepared by deacylating the appropriately blocked A-21978C complex or any of its appropriately blocked individual factors C0, C1, C2, C3, C4 or C5, with the desired acylating agent or an activated derivative thereof.

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