C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 9/09 (2006.01) C07F 9/10 (2006.01) C07F 9/11 (2006.01)
Patent
CA 2416808
A compound of the formula I: (see formula I) or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are the same or different, saturated or unsaturated aliphatic chain having from 2 to 30 carbon atoms. R3 is A-[CH2]m-B[CH2]n-C-[CH2]p-D, wherein m, n and p are each independently zero or an integer from 1 to 12, and A is carbonyl or oxygen, B is oxygen or a covalent bond, C is oxygen or a covalent bond, D is a covalent bond with the proviso that no two oxygen atoms are directly connected to each other and one of Z, and Z2 is absent and the other together with the phospho group forms a phospho ester of glycerol, choline, ethanolamine, inositol, or serine.
L'invention concerne des dérivés phosphorés de molécules lipophiles ramifiées utiles pour la perméabilisation de barrières biologiques et pour l'inhibition de la croissance de tumeur. L'invention concerne aussi des compositions pharmaceutiques comprenant ces molécules ainsi que leurs utilisations.
Beit-Yannai Eliezer
Kozak Alexander
Polyak Michael
Reznitsky-Cohen Dalia
Senderikhin Alexander
D-Pharm Ltd.
Gowling Lafleur Henderson Llp
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