C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 323/00 (2006.01) A61K 31/16 (2006.01) A61K 31/19 (2006.01) A61K 31/215 (2006.01) A61K 31/33 (2006.01) C07C 323/17 (2006.01) C07C 323/20 (2006.01) C07C 323/22 (2006.01) C07C 323/52 (2006.01) C07C 323/60 (2006.01) C07D 207/09 (2006.01) C07D 211/34 (2006.01) C07D 213/40 (2006.01) C07D 295/15 (2006.01) C07D 307/18 (2006.01) C07D 307/20 (2006.01) C07D 307/56 (2006.01) C07D 317/30 (2006.01) C07D 333/24 (2006.01) C07D 493/04 (2006.01)
Patent
CA 2120134
2120134 9310087 PCTABS00022 The present invention relates to compounds of formula (I) and the pharmaceutically acceptable salts thereof wherein R1, R2 and R10 are the same or different and independently represent alkyl, alkoxy, hydroxy, phenyl, halogen, trifluoromethyl, cyano, or hydrogen; q is 0 or 1; R3 represents hydrogen, alkyl, alkoxy, or hydroxy; X represents O, S or (CH2)m wherein m is an integer from 0 to 4; A represents O or S(O)n wherein n is 0, 1, or 2; Alk1 is straight or branched chain alkyl having 1 to 6 carbon atoms; p is 0 or 1; and R represents: (a) alkyl; (b) OH; (c) OR4 wherein R4 is alkyl of 1 to 6 carbon atoms; (d) NR5R6 wherein R5 is hydrogen or alkyl, and R6 is hydrogen, alkyl, alkoxyalkyl, heterocyclealkyl, substituted heterocyclealkyl, cycloalkyl, substituted cycloalkyl, phenyl, substituted phenyl, phenylalkyl, substituted phenylalkyl, or Alk-NR8R9 wherein Alk is alkyl of 1 to 10 carbon atoms and R8 and R9 each independently are hydrogen or alkyl; or NR5R6 together form a heterocyclic ring which may optionally be substituted; or (e) (CH2)tCOOR7 wherein t is an integer from 1 to 4 and r7 is hydrogen or alkyl of 1 to 4 carbon atoms. The compounds are inhibitors or stimulators of superoxide generation.
Mueller Richard August
Partis Richard Allen
G.d. Searle & Co.
Osler Hoskin & Harcourt Llp
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