C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 275/03 (2006.01) A61K 31/425 (2006.01) A61K 31/427 (2006.01) A61K 31/4427 (2006.01) A61K 31/4725 (2006.01) A61K 31/5377 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01) A61P 25/28 (2006.01) C07D 417/12 (2006.01)
Patent
CA 2592771
The present invention relates to certain novel compounds of the formula (I) to processes for preparing such compounds, to their the utility in modulation of nuclear hormone receptors Liver X Receptor (LXR) .alpha. (NR1H3) and/or .beta. (NR1H2) and in treating and/or preventing clinical conditions including cardiovascular diseases such as atherosclerosis; inflammatory diseases, Alzheimer's disease, lipid disorders (dyslipidemias) whether or not associated with insulin resistance, type 2 diabetes and other manifestations of the metabolic syndrome, to methods for their therapeutic use and to pharmaceutical compositions containing them.
La présente invention concerne certains nouveaux composés de formule (I); des méthodes de préparation desdits composés, leur utilisation dans la modulation des récepteurs nucléaires d'hormones, le récepteur X du foie (LXR), NR1H3 (LXRa) et/ou NR1H2 (LXRß) et dans le traitement et/ou la prévention d'états cliniques, dont les maladies cardiovasculaires telles que l'athérosclérose; de maladies inflammatoires; de la maladie d'Alzheimer; des troubles lipidiques (dyslipidémies), qu'ils soient associés ou non à la résistance à l'insuline, au diabète non insulino-dépendant ou à d'autres manifestations du syndrome métabolique. L'invention concerne l'utilisation thérapeutique desdits composés et des compositions pharmaceutiques contenant ces composés.
Bostrom Jonas
Brickmann Kay
Broo Anders
Holm Patrik
Judkins Robert
Astrazeneca Ab
Fetherstonhaugh & Co.
LandOfFree
Derivatives of isothiazol-3(2h)-one 1,1-dioxides as liver x... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Derivatives of isothiazol-3(2h)-one 1,1-dioxides as liver x..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Derivatives of isothiazol-3(2h)-one 1,1-dioxides as liver x... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1922491