C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
167/119, 260/429
C07F 15/00 (2006.01) A61K 31/695 (2006.01) C08G 77/398 (2006.01)
Patent
CA 2008908
DERIVATIVES OF PLATINUM (II) WITH POLYMETHYLSILOXANE, METHOD FOR PREPARING SAME AND ANTITUMOR AGENT BASED THEREON A b s t r a c t Derivatives of platinum (II) with pollymethylsiloxane comprising xerogels _ a product of interaction of a complex compound of platinum (II) in an aqueous solution of sodium chloride with a hydrogel of polymethylsiloxane at a molar ratio of Pt:Si:NaCl of 1-3:50:23-69 constituting a three- -dimensionally cross-linked polymer of a globular structure with a globule diameter of 4.0-7.0 nm and a specific surface area of 80-200 m2/g having a unit of the general formula: -{[PtCl(NH3)200 5]n (NaCl)5n(CH3SiO1.5)50(Na2O)10(H2O)20}- wherein n - 1 to 3. A method for preparing said compounds comprising reac- ting a complex compound of platinum (II) in an aqueous solu- tion of sodium chloride with a hydrogel of polymethylsiloxa- ne at a molar ratio of Pt:Si:NaCl = 1-3:50:23-69, followed by isolation of the desired product. The compounds of the invention exhibit an antitumor ac- tivity. The antitumor agent according to the present inven_ tion consists of an active principle - the compound of the present invention having a unit of the formula: -{[PtCl(NH3)2O0,5]2(NaCl)10(CH3SiO1.5)50(Na2O)10(H2O)20}-.
Budarin Lev I.
Girin Vitaly G.
Girin Vitaly N.
Keisevich Ljudvig V.
Maidanevich Nadezhda N.
Budarin Lev I.
Girin Vitaly G.
Girin Vitaly N.
Institut Fizicheskoi Khimii Imeni L.v.pisarzhevskogo Akademii Na
Keisevich Ljudvig V.
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