A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/437 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01)
Patent
CA 2663080
Compound corresponding to the general formula in which m and n are each the number 1 or 2, Ar is a group chosen from phenyl, naphth-1-yl, naphth-2-yl, pyridin-2-yl, pyridin-3-yl, pyridin-4-yl, furan-2-yl, furan-3-yl, thien-2-yl, thien-3-yl, thiazol-2-yl and oxazol-2-yl groups, it being possible for this group Ar to be optionally substituted; R is either a hydrogen atom, or one or more substituents, which may be identical to or different from one another, chosen from halogen atoms and mono- or polyfluoro(C1-C6)alkyl and mono- or polyfluoro(C1-C6)alkyloxy, linear (C1-C6)alkyl, branched or cyclic (C3-C7)alkyl, (C3-C7)cycloalkyl(C1-C6)alkyl, (C1-C6)alkoxy, (C3-C7)cycloalkyloxy, (C3-C7)cycloalkyl(C1-C6)alkyloxy, (C1-C6)alkylthio, cyano, amino, phenyl, acetyl, benzoyl, (C1-C6)alkylsulphonyl, carboxyl, (C1-C6)alkoxycarbonyl and pentafluorosulphanyl groups. Therapeutic use.
Composé répondant à la formule générale dans laquelle m et n représentent chacun le nombre 1 ou 2, Ar représente un groupe choisi parmi les groupes phényle, naphthyle-1, naphtyle-2, pyridin-2-yle, pyridin-3-yle, pyridin-4- yle, furan-2-yle, furan-3 yle, thién-2-yle, thién-3-yle, thiazol-2-yle et oxazol-2-yle, ce groupe Ar pouvant être éventuellement substitué; R représente soit un atome d'hydrogène, soit un ou plusieurs substituants identiques ou différents l'un de l'autre choisis parmi les atomes d'halogènes et les groupes mono- ou polyfluoro(C1-C6)alkyle et mono- ou polyfluoro(C1-C6)alkyloxy, (C1-C6)alkyles linéaires, (C3-C7)alkyles ramifiés ou cycliques, (C3-C7)cycloalkyl(C1-C6)alkyle, (C1-C6)alcoxy, (C3-C7)cycloalkyloxy, (C3-C7)cycloalkyl(C1-C6)alkyloxy, (C1-C6)alkylthio, cyano, amino, phényle, acétyle, benzoyle, (C1-C6)alkylsulfonyle, carboxy, (C1C6)alcoxycarbonyle etpentafluorosulfanyle. Application en thérapeutique.
Dargazanli Gihad
Estenne-Bouhtou Genevieve
Medaisko Florence
Renones Maria Carmen
Robic
Sanofi-Aventis
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