Derivatives of substituted cephalosporanic acid and...

Details Derivatives of substituted cephalosporanic acid and... Derivatives of substituted cephalosporanic acid and...

C - Chemistry, Metallurgy

07

D

260/104, 167/187

C07D 501/24 (2006.01) A61K 31/545 (2006.01) C07D 501/20 (2006.01) C07D 501/22 (2006.01) C07D 501/26 (2006.01) C07D 501/36 (2006.01)

Patent

CA 1254884

TITLE OF THE INVENTION: DERIVATIVES OF SUBSTITUTED CEPHALOSPORANIC ACID AND ANTIBIOTICS COMPRISING THE SAME ABSTRACT OF THE DISCLOSURE: Disclosed herein are the derivatives of substituted cephalosporanic acid represented by the formula (I): Image (I) wherein R1 represents a 4-pyridylthiomethyl group, an alpha- aminobenzyl group, a cyanomethyl group or a 1-tetrazolylmethyl group; R2 represents a hydrogen atom, an acetoxy group or a (5-methyl-1,3,4-thiadiazol-2-yl)thio group; R3 represents a hydrogen atom, a hydroxyl group, a carbamoyl group, an alkyl group having 1 to 4 carbon atoms or -(CONH) (CH2)n-COOH wherein m is 0 or 1, n is 0, 1 or 2 or a salt or ester thereof formed at the carboxyl group; p is 0, 1 or 2 and X represents carbon atom or nitrogen atom, and antibiotics comprising the derivatives of substituted cephalosporanic acid represented by the formula (I).

444436

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