C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
167/202, 260/229
C07H 19/16 (2006.01) A61K 31/70 (2006.01) C07D 405/14 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01) C07H 19/14 (2006.01) C07H 19/20 (2006.01)
Patent
CA 1311201
ABSTRACT Desazapurine-nucleoside derivatives, processes for the preparation thereof, pharmaceutical compositions containing them and the use thereof for nucleic acid sequencing and as antiviral agents The present invention provides desazapurine- nucleoside derivatives of the general formula:- (I) Image wherein X is a nitrogen atom or a methine radical, W is a nitrogen atom or a Image radical, R1, R2, R3 and R4, which can be the same or different 3 are hydrogen or halogen atoms, hydroxyl or mercapto groups, lower alkyl, lower alkylthio, lower alkoxy, aralkyl, aralkoxy or aryloxy radicals or amino groups optionally substituted once or twice, R5 is a hydrogen atom or a hydroxyl group, R6 and R7 are each hydrogen atoms or one of them is a halogen atom or a cyano or azido group or an amino group optionally substituted once or twice, whereby one of R6 and R7 can also be a hydroxyl group when X is a methine radical and, in addition, R5 and R7 can together also represent a further valency bond between C-2' and C-3' and is a hydrogen atom or a mono-, di- or tri-phosphate group, as well as the tautomers and salts thereof and nucleic acids which contain one or more compounds of general formula (I) as structural components; these new compounds are use- ful for nucleic acid sequencing and as antiviral agents.
563635
Batz Hans-Georg
Bourgeois Werner
Kaiser Klaus
Muhlegger Klaus
Muth Heinz-Peter
Boehringer Mannheim Gmbh
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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