Detection and use of antiviral resistance mutations

C - Chemistry – Metallurgy – 12 – N

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C12N 15/51 (2006.01) C12N 7/00 (2006.01) C12Q 1/70 (2006.01)

Patent

CA 2655175

The present invention relates generally to viral variants exhibiting reduced sensitivity to particular agents and/or reduced interactivity with immunological reagents. More particularly, the present invention is directed to hepatitis B virus (HBV) variants exhibiting complete or partial resistance to nucleoside or nucleotide analogs and/or reduced interactivity with antibodies to viral surface components including reduced sensitivity to these antibodies. Vaccines and diagnostic assays are also contemplated herein.

La présente invention concerne d'une manière générale des variants viraux présentant une sensibilité réduite à des agents particuliers et/ou une interactivité réduite avec des réactifs immunologiques. Plus particulièrement, la présente invention concerne des variants du virus de l'hépatite B (HBV) qui présentent une résistance totale ou partielle à des analogues de nucléosides ou de nucléotides et/ou une interactivité réduite avec des anticorps dirigés contre les composants de la surface virale, impliquant une sensibilité réduite à ces anticorps. La présente invention concerne également des vaccins et des essais diagnostiques.

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