G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/48 (2006.01) C12M 1/00 (2006.01) C12M 1/34 (2006.01) C12Q 1/02 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01)
Patent
CA 2484058
A device for monitoring leukocyte migration is provided. The invention also provides a method of using the device to monitor leukocyte migration in the presence of physiological shear flow and therefore simulate physiological conditions of a blood vessel in vivo. The invention further provides a method of using the device to high-throughput screen a plurality of test agents. The present invention further provides a flexible assay system and numerous assays that can be used to test biological interactions and systems. Laminar flow gradients are employed mimic gradient situations present in vivo.
L'invention concerne un dispositif destiné à contrôler la migration des leucocytes. Elle concerne également un procédé mettant en oeuvre le dispositif de l'invention pour contrôler la migration des leucocytes en présence d'un écoulement de cisaillement physiologique, et ainsi simuler des états physiologiques d'un vaisseau sanguin in vivo. L'invention concerne aussi un procédé d'utilisation du dispositif pour cribler à haute capacité plusieurs substances d'essai. Elle concerne en outre un système de dosage souple et de nombreux dosages pouvant être mis en oeuvre pour tester des interactions et des systèmes biologiques. Des gradients d'écoulement laminaire sont utilisés pour simuler des situations de gradient présentes in vivo.
Aumond Bernardo
Benoit Brian
Brown Matthew
Cruceta Johanna
Kim Enoch
Aumond Bernardo
Benoit Brian
Borden Ladner Gervais Llp
Brown Matthew
Cruceta Johanna
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