A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/00 (2006.01) A61K 31/50 (2006.01) A61K 31/56 (2006.01) A61K 31/566 (2006.01) A61K 31/575 (2006.01) A61K 31/58 (2006.01) A61K 31/655 (2006.01) C08L 83/12 (2006.01)
Patent
CA 2395226
This invention relates to a device for the controlled release over a prolonged period of time of a drug having an- tiprogestinic properties, said device comprising - a core comprising said drug,- optionally a membrane encasing said core, wherein said core and/or membrane is made of a siloxane-based elastomer composition comprising at least one elastomer and possibly a non-crosslinked polymer. The device is characterized in that - the elastomer composition comprises poly(alkylene oxide) groups and that the poly(alkylene oxide) groups are present in the elastomer or polymer as alkoxy-terminated grafts of polysiloxane units, or as blocks, the said grafts or blocks being linked to the polysiloxane units by silicon-carbon bonds, or as a mixture of these forms.
L'invention concerne un dispositif destiné à la libération régulée pendant une durée prolongée d'un médicament doté de propriétés antiprogestatives. Ce dispositif comprend un noyau contenant ce médicament et éventuellement une membrane enveloppant ce noyau. Ce noyau et/ou membrane est constitué d'une composition élastomère à base de siloxane comprenant au moins un élastomère et éventuellement un polymère non réticulé. Ce dispositif se caractérise en ce que ladite composition élastomère renferme des groupes poly(alkylène oxyde), et en ce que ces groupes poly(alkylène oxyde) sont présents dans ledit élastomère ou polymère en tant que greffes à terminaison alcoxy d'unités polysiloxane, ou en tant que de blocs, lesdites greffes ou lesdits blocs étant liés aux unités polysiloxane par des liaisons silicium-carbone, ou bien en tant que mélange de ces formes.
Ala-Sorvari Juha
Haapakumpu Timo
Jukarainen Harri
Lehtinen Matti
Markkula Tommi
Bayer Schering Pharma Oy
Leiras Oy
Robic
LandOfFree
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