Devices for transcutaneous delivery of vaccines and...

A - Human Necessities – 61 – M

Patent

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A61M 35/00 (2006.01)

Patent

CA 2620943

The invention provides devices for the disruption of one or more layers of skin and methods of their use to administer therapeutic agents, e.g., antigens or drugs. The devices are designed to disrupt a defined area of skin. The defined area can approximate the area that a patch or other suitable vehicle for therapeutic agent, e.g., drug or vaccine, delivery is designed to contact. Exemplary devices employ a mask to define the area to be disrupted. Other devices disrupt a defined area by rotating in place. For devices that employ a mask that is secured to the skin, the invention provides methods of disrupting the stratum corneum by first securing the mask to the skin and then disrupting the skin. For rotating devices, the disrupting member is simply placed against the skin and actuated to effect disruption.

L'invention concerne des dispositifs de percement d~une ou de plusieurs couches de peau et des procédés d~utilisation de ceux-ci pour administrer des agents thérapeutiques, par exemple, des antigènes ou des médicaments. Les dispositifs sont conçus pour percer une zone de peau définie. La zone définie peut correspondre à la zone avec laquelle un patch ou autre véhicule adéquat pour l'administration d'un agent thérapeutique, par exemple un médicament ou un vaccin, doit entrer en contact. Des dispositifs exemplaires emploient un masque pour définir la zone à percer. D~autres dispositifs percent une surface définie en tournant sur place. Pour les dispositifs employant un masque fixé à la peau, on propose des procédés de percement de la strate de cornée en fixant d~abord le masque à la peau, avant de percer la peau. Pour les dispositifs rotatifs, l~élément de percement est simplement placé contre la peau et actionné pour réaliser le percement.

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