C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 279/22 (2006.01) A61K 31/16 (2006.01) A61K 31/395 (2006.01) A61K 49/00 (2006.01) C07C 317/32 (2006.01) C07C 317/44 (2006.01) C07C 323/44 (2006.01) C07D 207/337 (2006.01) C07D 211/14 (2006.01) C07D 213/70 (2006.01) C07D 215/20 (2006.01) C07D 233/64 (2006.01) C07D 295/155 (2006.01) C07D 521/00 (2006.01)
Patent
CA 2130703
Diacyl-substituted guanidines of the formula I (see formula I) are described where X(1) and x(2) are (see formula II) T1 is zero, 1, 2, 3 or 4, R(A) and R(B) are hydrogen, Hal, CN, OR(106), (O)(cyclo)- (fluoro)alkyl, NR(107)R(108), phenyl or benzyl, or X(1) and x(2) are (see formula III) T2a and T2b are, independently of each other, zero, 1 or 2, where the double bond can be in the E or Z con- figuration; or X(1) and X(2) arm (see formula IV) as are the pharmaceutically tolerated salts thereof. They are outstandingly suitable for use as antiarrhythmic pharmaceuticals possessing a cardioprotective component for the prophylaxis and treatment of infarction and for the treatment of angina pectoris, in connection with which they also inhibit or strongly reduce, in a preventive manner, the pathophysiological processes associated with the genesis of ischemically induced damage, in particular associated with the elicitation of ischemically induced cardiac arrhythmias. On account of their protective effects against pathological hypoxic and ischemic situations, the compounds of the formula I according to the invention can, as a consequence of inhibiting the cellular Na+/H+ exchange mechanism, be used as pharmaceuticals for treating all acute or chronic damage elicited by ischemia, or diseases induced primarily or secondarily thereby.
Albus Udo
Crause Peter
Kleemann Heinz-Werner
Lang Hans-Jochen
Scholz Wolfgang
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Hoechst Aktiengesellschaft
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