G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/564 (2006.01)
Patent
CA 2377733
Method for diagnosis of autoimmune diseases of the GSE-type or associated with gluten sensitive enteropathy comprising taking a sample and testing the sample for antibodies against human tissue transglutaminase, tissue-specific transglutaminases, or other transglutaminases. It was found that autoimmune diseases other than coeliac disease can be diagnosed and distinguished in this way, notably, dermatitis herpetiformis Duhring, Crohn's disease, Addison's disease, AI haemolytic anaemia, AI thrombocytopenic purpura, AI thyroid diseases, atrophic gastritis - pernicious anaemia, IgA nephropathy or IgA glomerulonephritis, myasthenia gravis, partial lipodystrophy, polymyositis, primary biliary cirrhosis, primary sclerosing cholangitis, recurrent pericarditis, relapsing polychondritis, rheumatoid arthritis, rheumatism, sarcoidosis, Sjögren's syndrome, SLE, splenic atrophy, type I (insulin- dependent) diabetes mellitus, diabetis mellitus of other types, ulcerative colitis, vasculitis (both systemic and cutaneous), vitiligo as well as autoimmune diseases associated with infertility, increased risk of abortion, or reduced foetal growth.
La présente invention concerne des techniques de diagnostic de pathologies auto-immunes du type de l'entéropathie par intolérance au gluten ou associées à l'entéropathie par intolérance au gluten. Pour cette technique, on prend un échantillon, et on y recherche des anticorps dirigés contre la transglutaminase tissulaire humaine, des transglutaminases spécifiques de tissus, ou d'autres transglutaminases. Il est apparu que cette technique permet le diagnostic et la reconnaissance de pathologies auto-immunes autres que les affections coeliaques, et notamment, la dermatite herpétiforme de Duhring, la maladie de Crohn, la maladie d'Addison, l'anémie hémolytique auto-immune, purpura thrombocytopénique auto-immune, thyroïdites auto-immunes, gastrite atrophique anémie pernicieuse, maladie de Berger, myasthénie grave, maladie de Simons, polymyosite, cirrhose hypertrophique de Hanot-Gilbert, angiocholite sclérosante primitive, péricardite récidivante, polychondrite chronique atrophiante, polyarthrite rhumatoïde, rhumatisme, sarcoïdose, syndrome de Sjögren, lupus érythémateux aigu disséminé, atrophie splénique, diabète insulino-dépendant (de type I), diabètes sucrés d'autres types, rectocolite hémorragique, vascularite (aussi bien systémique que cutanée), vitiligo ainsi que pathologies auto-immunes associées à la stérilité, aux risques accrus d'avortement, ou à la mauvaise croissance du foetus.
Aeschlimann Daniel
Karpati Sarolta
Odenthal Uwe
Paulsson Mats
Sardy Miklos
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Immundiagnostik Ag
Paulsson Mats
Wieslab Ab
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