Diagnosis of kidney damage and protection against same

Details Diagnosis of kidney damage and protection against same Diagnosis of kidney damage and protection against same

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 38/22 (2006.01) A61K 38/43 (2006.01) A61P 13/12 (2006.01) C07K 14/47 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2497400

Various nucleic acids and proteins have been identified by differential hybridization methods as useful as markers for diagnosing kidney damage. The identified marker proteins include (I) androgen related protein, SON protein, FUSE binding Protein 1, claudin10, heat shock protein, phospho triesterase related protein, ubiquitin protein ligase Nedd-4, and Ac39/physophilin, and (II) disabled-2 p96, palmitylated serine/threonine kinase, tumor differentially expressed 1 protein, cytochrome oxidase III, TLH 39 protein precursor, hydroxysteroid dehydrogenase 4 delta <5>-3 beta, and glutathione peroxidase III. The proteins of group (I), and antagonists of the proteins of group (II), are useful for protecting mammals against kidney damage.

On a identifié, avec des méthodes d'hybridation différentielle, divers acides nucléiques et diverses protéines qui sont utiles en tant que marqueurs pour le diagnostic des lésions rénales. Les protéines marqueurs identifiées comprennent (I) la protéine d'androgène, la protéine SON, la protéine de liaison 1 FUSE, la claudine 10, la protéine de choc thermique, la protéine liée à la phosphotriestérase, la ligase de protéine ubiquitine Nedd-4 et la Ac39/physophiline, ainsi que (II) la p96 2-déficiente, la sérine/thréonine kinase palmitylée, la protéine 1 exprimée différentiellement dans les tumeurs, la cytochrome oxydase III, le précurseur de protéine TLH 39, la déshydrogénase d'hydroxystéroïde 4 delta <5>-3 bêta et la glutathione peroxydase III. Les protéines du groupe (I) et les antagonistes des protéines du groupe (II) sont utiles pour protéger les mammifères contre les lésions rénales.

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