Diagnosis of sepsis using mitochondrial nucleic acid assays

Details Diagnosis of sepsis using mitochondrial nucleic acid assays Diagnosis of sepsis using mitochondrial nucleic acid assays

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2491026

The invention provides assays to detect sepsis disease states in a subject by determining the relative amount of mitochondrial nucleic acid in the subject. The assays of the invention may include PCR assays, such semi-quantitative or quantitative PCR involving the co-amplification of a mitochondrial sequence and a reference sequence, such as a genomic sequence. Information from such assays may be evaluated to provide a ratio of mitochondrial nucleic acid to nuclear nucleic acid in the cells of the subject.

L'invention concerne des épreuves biologiques permettant de détecter des étapes pathologiques de sepsis chez un sujet, par le biais de la détermination de la quantité relative d'acides nucléiques mytochondriaux chez le sujet. Ces épreuves biologiques peuvent comprendre des épreuves biologiques PCR, un tel PCR semi quantitatif ou quantitatif impliquant la coamplification d'une séquence mytochondriale et d'une séquence de référence, notamment une séquence génomique. Des informations provenant de ces épreuves biologiques peuvent être évaluées pour fournir un rapport d'acides nucléiques mytochondriaux par rapport aux acides nucléiques du noyau des cellules du sujet.

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