G - Physics – 01 – N
Patent
G - Physics
01
N
167/129, 167/45,
G01N 33/53 (2006.01)
Patent
CA 1302250
DIAGNOSTIC FOR ALZHEIMER'S DISEASE ABSTRACT OF THE DISCLOSURE It has been discovered that paired helical filament antigens, that are cross-reactive with the paired helical filament isolated from brains of persons who suffered from Alzheimer's Disease, are found at elevated levels in cerebral spinal fluid of persons suffering from said disease. Thus, a method is provided for indicating whether a person suffers from Alzheimer's Disease by measuring the level of paired helical filament antigens in a specimen of the person's cerebral spinal fluid. It has been discovered, further, that a major component of paired helical filament in brains of Alzheimer's Disease patients and of paired helical filament antigens in cerebral spinal fluid of persons suffer from the disease is abnormally phosphorylated microtubule-associated proteins known as tau. Thus, the invention also provides a method for indicating whether a person suffers from Alzheimer's Disease by testing for the presence of abnormally phosphorylated tau proteins in a specimen of the persons' cerebral spinal fluid.
533788
Grundke-Iqbal Inge
Iqbal Khalid
Kascsak Richard J.
Mehta Pankaj D.
Wang Gian Ping
Macrae & Co.
Research Foundation For Mental Hygiene Inc.
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