A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 51/04 (2006.01)
Patent
CA 2514885
The present invention relates to the field of diagnostic imaging. Specifically, the invention relates to the diagnostic imaging of diseases where specific matrix metalloproteinases are known to be involved. One embodiment of the invention is a compound having matrix metalloproteinase inhibitory activity suitable for diagnostic imaging. Also disclosed in the present invention is a pharmaceutical composition comprising the diagnostic imaging agent of the invention in a form suitable for mammalian administration. The invention furthermore discloses intermediates in the synthesis of the diagnostic imaging agents of the invention and kits for the preparation of the pharmaceutical composition of the invention. The pharmaceutical composition of the invention may be used in the diagnosis of diseases where specific matrix metalloproteinases are known to be involved.
L'invention concerne le domaine de l'imagerie diagnostique et notamment l'imagerie diagnostique de maladies dans lesquelles on sait que des métalloprotéinases matricielles spécifiques sont impliquées. Dans un mode de réalisation, l'invention porte sur un composé possédant une activité inhibitrice des métalloprotéinases matricielles convenant à l'imagerie diagnostique. L'invention se rapporte également à une préparation pharmaceutique comprenant l'agent d'imagerie diagnostique de l'invention sous une forme appropriée à l'administration au mammifère. Elle concerne encore des intermédiaires dans la synthèse desdits agents d'imagerie diagnostique de l'invention et des kits pour la préparation de la composition pharmaceutique de l'invention. La composition pharmaceutique de l'invention peut être utilisée dans le diagnostic de maladies dans lesquelles on sait que les métalloprotéinases matricielles sont impliquées.
Arukwe Joseph
Breyholz Hans-Jorg
Cuthbertson Alan
Davis Julie
Heywood Kirsty
Fetherstonhaugh & Co.
Ge Healthcare Limited
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