C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 275/26 (2006.01) A61K 31/17 (2006.01) A61K 31/41 (2006.01) A61P 19/00 (2006.01) A61P 43/00 (2006.01) C07C 275/28 (2006.01) C07C 275/30 (2006.01) C07C 275/42 (2006.01) C07D 207/00 (2006.01) C07D 207/16 (2006.01) C07D 209/40 (2006.01) C07D 213/75 (2006.01) C07D 213/81 (2006.01) C07D 231/40 (2006.01) C07D 257/04 (2006.01) C07D 277/48 (2006.01) C07D 295/192 (2006.01) C07D 307/68 (2006.01) C07D 333/36 (2006.01) C07D 401/12 (2006.01) C07F 9/38 (2006.01) C07F 9/58 (2006.01)
Patent
CA 2495284
The present invention relates to novel diarylurea derivatives represented by general formula (I) useful as chloride channel blockers. In other aspects the invention relates to the use of these compounds in a method for therapy, such as for the treatment of bone metabolic diseases, diseases responsive to modulation of the mast cell or basophil activity, diseases responsive to inhibition of angiogenesis, or sickle cell anaemia, and to pharmaceutical compositions comprising the compounds of the invention.
L'invention concerne de nouveaux dérivés de diarylurée utilisés comme bloqueurs de canaux chlorure. Selon d'autres aspects, l'invention concerne l'utilisation de ces composés dans un procédé de thérapie, par exemple, pour le traitement de maladies métaboliques osseuses, de maladies responsables de la modulation de basophile/mastocyte ou de l'activité basophilique, de maladies responsables de l'inhibition de l'angiogénèse, ou d'anémies de cellules falciformes du sang. L'invention concerne en outre des compositions pharmaceutiques comprenant les composés de l'invention.
Christophersen Palle
Dahl Bjarne H.
Engsig Michael Thyrring
Foged Niels Taekker
Jensen Flemming Reissig
Mccarthy Tetrault Llp
Neurosearch A/s
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