Diazacarbazoles and methods of use

Details Diazacarbazoles and methods of use Diazacarbazoles and methods of use

C - Chemistry, Metallurgy

07

D

C07D 471/14 (2006.01) A61K 31/519 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2726114

The invention relates to 1,5-diazacarbazole compounds of Formula (I), (I-a), (I-b), (I-c), (I-d), (I-e), (I-f), (I-g) and (I-h) which are useful as kinase inhibitors, more specifically useful as checkpoint kinase 1 (chkl) inhibitors, thus useful as cancer therapeutics. The invention also relates to compositions, more specifically pharmaceutical compositions comprising these com-pounds and methods of using the same to treat various forms of cancer and hyperproliferative disorders, as well as methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological condi-tions.

La présente invention concerne des composés 1,5-diazacarbazole de formule (I), (I-a), (I-b), (I-c), (I-d), (I-e), (I-f), (I-g) et (I-h) qui peuvent être utilisés comme inhibiteurs des kinases, plus spécifiquement comme inhibiteurs des checkpoint kinases 1 (chkl), et donc comme agents thérapeutiques anticancéreux. Linvention concerne également des compositions, plus spécifiquement des compositions pharmaceutiques comprenant ces composés et des procédés permettant de les utiliser pour traiter diverses formes de cancer et de troubles hyperprolifératifs, ainsi que des procédés dutilisation des composés pour le diagnostic ou le traitement in vitro, in situ, et in vivo de cellules de mammifères, ou daffections pathologiques associées.

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