Difluorostatone antiviral agents

Details Difluorostatone antiviral agents Difluorostatone antiviral agents

C - Chemistry, Metallurgy

07

C

167/215, 167/228

C07C 237/22 (2006.01) A61K 31/16 (2006.01) C07C 271/20 (2006.01) C07C 271/22 (2006.01) C07D 211/40 (2006.01) C07D 211/74 (2006.01) C07D 213/30 (2006.01) C07D 213/40 (2006.01) C07D 213/56 (2006.01) C07D 213/81 (2006.01) C07D 213/82 (2006.01) C07D 233/61 (2006.01) C07D 295/15 (2006.01) C07D 295/185 (2006.01) C07D 295/192 (2006.01) C07D 295/26 (2006.01) C07D 521/00 (2006.01) C07F 7/10 (2006.01)

Patent

CA 2195125

The present invention provides novel difluorostatone derivatives of general formula (I), which are useful as antiviral agents. More specifically, these novel compounds are useful as inhibitors of retroviral proteases required for replication, particularly the HIV-1 and HIV-2 viral proteases, in the prevention or treatment of infection by the human immunodeficiency virus (HIV), and in the treatment of consequent pathological conditions such as the acquired immunodeficiency syndrome (AIDS) in mammals capable of being infected with HIV virus.

La présente invention concerne de nouveaux dérivés de difluorostatone représentés par la formule générale (I). Ces dérivés sont utiles comme agents antiviraux. Plus spécifiquement, ces nouveaux composés sont utiles comme inhibiteurs de protéases rétrovirales nécessaires à la réplication, notamment les protéases virales des VIH-1 et VIH-2, dans la prévention ou le traitement de l'infection par le virus de l'immunodéficience humaine (VIH), et dans le traitement d'états pathologiques qui en découlent tels que le syndrome d'immunodéficience acquise (SIDA) chez les mammifères susceptibles d'être infectés par le virus VIH.

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