Dihydrobenzofuran carboxamides and process for their...

C - Chemistry – Metallurgy – 07 – D

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C07D 451/00 (2006.01) A61K 31/435 (2006.01) C07D 451/04 (2006.01) C07D 451/14 (2006.01) C07D 453/06 (2006.01) C07D 455/02 (2006.01) C07D 471/02 (2006.01) C07D 471/08 (2006.01)

Patent

CA 2058264

A compound of formula (I) Image (I) wherein A is a substituent selected from the group consisting of a) Image ; b) Image ; c) Image and d) Image wherein R' is hydrogen or methyl, m is zero or 1 and the symbol ~ means that the azabicyclic rings may be in the ~ or the ~ orientation, and the pharmaceutically acceptable salts thereof, are useful in treating CNS disorders, gut motility disorders, and/or emesis and/or pain in mammals, and/or migraine.

Un composé de formule (I) Image (I), dans laquelle A est un substituant choisi dans le groupe constitué de a) Image ; de b) Image ; de c) Image et de d) Image , dans laquelle R' est un atome d'hydrogène ou un groupement méthyle, m est égal à zéro ou à 1, et le symbole ~ signifie que les noyaux azabicycliques peuvent être orientés en alpha ou en bêta, ainsi que des sels correspondants utilisables en pharmacie sont utiles pour traiter des troubles du SNC, des troubles de transit intestinal et/ou des vomissements et/ou de la douleur chez les mammifères, et/ou de la migraine

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