Dihydrodibenzo[b,e]oxazepine derivatives and pharmaceutical...

Details Dihydrodibenzo[b,e]oxazepine derivatives and pharmaceutical... Dihydrodibenzo[b,e]oxazepine derivatives and pharmaceutical...

C - Chemistry, Metallurgy

07

D

C07D 413/06 (2006.01) A61K 31/55 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2261271

The invention relates to novel 5,11-dihydrodi- benzo[b,e][1,4]oxazepine derivatives represented by formula [I]: (see formula I) wherein R1 and R2 are the same or different and each represents a hydrogen atom, a halogen atom, a cyano group, a hydroxy group or a C1-C5 alkoxy group, or R1 and R2 together form -O(CH2)n O- in which n is 1, 2 or 3, R3 represents a hydrogen atom or hydroxy group, R4 and R5 are the same or different and each represents a hydrogen atom or hydroxy group, or R4 and R5 together form =O group, stereoisomers thereof, pharmacologically acceptable salts thereof, and hydrates thereof. The compounds of the invention are useful for treating digestive tract abnormal moving function diseases.

Dérivés de 5,11-dihydrodibenz[b,e] [1,4]oxazepine, par exemple la (R)-(+)-5,11-dihydro-5-[1-(4-méthoxyphénéthyl)-2-pyrrolidinylméthyl]dibenz[b,e] [1,4]oxazepine ou la (R)-(+)-5,11-dihydro-5-[1-(4-fluorophénéthyl)-2-pyrrolidinylméthyl]dibenz[b,e] [1,4]oxazepine; leurs stéréoisomères, leurs sels pharmacologiquement acceptables et leurs hydrates; et compositions médicamenteuses les comportant. Ces composés présentent une excellente activité d'amélioration de la fonction motrice du tube digestif sans effets secondaires indésirables.

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