C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/14 (2006.01) A61K 31/445 (2006.01) C07D 209/00 (2006.01) C07D 221/00 (2006.01) C07D 235/00 (2006.01)
Patent
CA 2447588
The invention concerns dihydroimidazo[5,1-a]-.beta.-carboline compounds of general formula (I), wherein in particular: R¿1?, R¿2?, R¿2?, R¿4?, R¿6? and R¿7?, identical or different, independently of one another, represent a hydrogen, halogen atom, an alkyl, hydroxy, alkoxy, trihalogenoalkyl, alkylamino, dialkylamino, aryl, arylalkyl, carboxy, alkylcarbonyloxy, acyl, aryloxy or arylalkoxy group; R¿5? represents a hydrogen atom, an alkyl or arylalkyl group; and their isomers as well as their addition salts to a pharmaceutically acceptable acid. The inventive compounds are for use as medicine, in particular as hypnotic.
La présente invention concerne des composés de hihydroimidazo [5, 1-a]-.beta.- carboline de formule générale (I) dans laquelle notamment : R1, R2, R3, R4, R6, et R7, identiques ou différents, indépendamment l'un de l'autre, représentent un atome d'hydrogène, d'halogène, un groupement alkyle, hydroxy, alkoxy, trihalogénoalkyle, alkylamino, dialkylamino, aryle, arylalkyle, carboxy, alkylcarbonyloxy, acyle, aryloxy ou arylalkoxy, R5 représente un atome d'hydrogène, un groupement alkyle, ou arylalkyle, et leurs isomères ainsi que leurs sels d'addition à un acide pharmaceutiquement acceptable. Application a titre de médicament, en particulier comme hypnotique.
Fourtillan Jean-Bernard
Fourtillan Marianne
Jacquesy Jean-Claude
Karam Omar
Tafani Jean-Pierre
Macef
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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