C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 495/04 (2006.01) A61K 31/4365 (2006.01) A61P 11/06 (2006.01) C07D 211/90 (2006.01) C07D 497/04 (2006.01)
Patent
CA 2410655
This invention relates to novel dihydropyridine soft drugs of the formula .PHI.OOR~1, where .PHI. is a dihydropyridine moiety. These compounds are useful as calcium channel antagonists with cardiovascular, antiasthmatic and antibroncho-constriction activity. Use of such soft drug analogs permits the administration of greater doses of the claimed dihydropyridine compounds without intolerable systemic effects. Thus, this invention also provides pharmaceutical compositions, as well as methods, for preventing and treating disorders such as hypersensitivity, allergy, asthma, bronchospasm, dysmenorrhea, esophageal spasm, glaucoma, premature labor, urinary tract disorders, gastrointestinal motility disorders and cardiovascular disorders, while avoiding unwanted systemic effects.
L'invention concerne de nouveaux médicaments à base de dihydropyridine de formule PHI OOR1, où PHI est une fraction de dihydropyridine. Ces composés s'avèrent utiles en tant qu'antagonistes des canaux calciques développant une activité cardiovasculaire, antiasthmatique et anti-bronchoconstriction. L'utilisation d'analogues de tels médicaments permet d'administrer des doses plus importantes desdits composés de dihydropyridine sans provoquer d'effets systémiques. La présente invention concerne également des compositions pharmaceutiques, ainsi que des méthodes de prévention et de traitement de troubles divers tels qu'hypersensibilité, manifestations allergiques, asthme, bronchospasme, dysménorrhée, spasme de l'oesophage, glaucome, accouchement prématuré, troubles de l'appareil urinaire, troubles de la motilité gastro-intestinale et pathologies cardio-vasculaires, tout en évitant des effets systémiques indésirables.
Bullington James L.
Dodd John H.
Hall Daniel A.
Henry James R.
Rupert Kenneth C.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Ortho-Mcneil Pharmaceutical Inc.
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