C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/5517 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2582985
The present invention provides compounds of the formula (I) wherein R1, R2, R3 and R4 are described herein. The invention also provides syntheses for preparation of such compounds and pharmaceutical compositions containing them. The invention further provides methods for inhibiting kinases, in particular CDK2, for inhibiting angiogenesis, and for treating cancers, in particular breast, colon, prostate, and lung cancer.
La présente invention se rapporte à des composés représentés par la formule (I), dans laquelle R1, R2, R3 et R4 sont tels que définis dans le descriptif de l'invention. L'invention a également trait à des procédés de préparation de tels composés et de compositions pharmaceutiques les contenant. L'invention concerne aussi des procédés permettant d'inhiber des kinases, en particulier CDK2, d'inhiber l'angiogenèse, et de traiter des cancers, en particulier les cancers du sein, du colon, de la prostate et du poumon.
Liu Jin-Jun
Luk Kin-Chun
Pizzolato Giacomo
Ren Yi
Thakkar Kshitij Chhabilbhai
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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