C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/70 (2006.01)
Patent
CA 2636727
Embodiments herein provide for methods, compositions and apparati for detection and/or diagnosis of virus types, subtypes and/or strains. In particular embodiments, the virus is an influenza virus. The apparatus may include a microarray with attached capture probes, designed to bind to oligonucleotides capable of binding at least a portion of a nucleic acid sequence of one or more target genes in a broad array of influenza types, subtypes or strains. The compositions may include isolated nucleic acids as capture probes, target sequences and/or tagged label probes, of use for diagnosis and/or detection of influenza virus.
L'invention concerne des modes de réalisation comprenant des procédés, des compositions et des appareils de détection et/ou de diagnostic de types, sous-types et/ou de souches de virus. Dans des modes de réalisation particuliers, le virus est un virus de la grippe. L'appareil peut comprendre un microarray (assemblage organisé d'entités chimiques, biologiques ou cellulaires) auquel sont fixées des sondes de capture, conçues pour se lier aux oligonucléotides capables de lier au moins une portion d'une séquence d'acide nucléique d'un ou de plusieurs gènes cibles dans un large réseau de types, sous-types ou souches de grippe. Les compositions peuvent contenir des acides nucléiques isolés comme sondes de capture, séquences cibles et/ou sondes marquées par un marqueur, pour diagnostiquer et/ou détecter le virus de la grippe.
Cox Nancy
Dawson-Tenent Erica
Kuchta Robert
Mehlmann Daniela
Mehlmann Martin
Centers For Disease Control And Prevention
Regents Of The University Of Colorado
Smart & Biggar
LandOfFree
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