Domain antibody construct

Details Domain antibody construct Domain antibody construct

C - Chemistry, Metallurgy

07

K

C07K 16/24 (2006.01) A61K 39/395 (2006.01) A61P 9/00 (2006.01) A61P 25/28 (2006.01) A61P 27/00 (2006.01) A61P 37/00 (2006.01) C07K 16/46 (2006.01) C12N 15/13 (2006.01)

Patent

CA 2640661

The present invention provides a domain antibody construct which binds to human TNF-.alpha., the construct comprising: (a) a domain antibody (dAb) which binds to human TNF-.alpha.; (b) a modified hinge region sequence; (c) a human or primate heavy chain constant region sequence having a truncated CH1 domain of not more than 20 residues, wherein said modified hinge region sequence contains either a deletion or a single amino acid substitution of at least one cysteine residue which normally facilitates disulfide bond formation between heavy and light antibody chains.

La présente invention concerne un produit d'assemblage d'anticorps à domaines qui se lie au TNF-.alpha. humain, le produit d'assemblage comprenant : (a) un anticorps à domaine (dAb) qui se lie au TNF-.alpha. humain ; (b) une séquence de région charnière modifiée ; (c) une séquence de région constante à chaîne lourde humaine ou simiesque ayant un domaine CH1 tronqué non supérieur à 20 résidus, ladite séquence de région charnière modifiée contenant soit une suppression, soit une substitution d'acides aminés unique d'au moins un résidu cystéine qui facilite normalement la formation d'un pont disulfure entre les chaînes lourdes et légères de l'anticorps.

Affiliated with

Also associated with

Rating

Domain antibody construct does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Domain antibody construct, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Domain antibody construct will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-2069533