Dopamine transporter imaging agents

Details Dopamine transporter imaging agents Dopamine transporter imaging agents

C - Chemistry, Metallurgy

07

D

C07D 451/02 (2006.01) A61K 51/04 (2006.01)

Patent

CA 2285516

Radiopharmaceutical compounds are disclosed. A tropane compound is linked through the N atom at the 8-position to a chelating ligand capable of complexing technetium or rhenium to produce a neutral labeled complex that selectively binds to the dopamine transporter over the serotonin transporter with a ratio of 10 or more. These compounds can be prepared as separate diastereoisomers as well as a mixture of diastereoisomers. Also disclosed are radiopharmaceutical kits for preparing the labeled radiopharmaceutical compounds.

Des composés radiopharmaceutiques sont divulgués dans cette invention. Un composé tropane se fixe par son atome N en position 8 à un ligand chélateur capable de former un complexe avec le technétium ou le rhénium pour donner un complexe neutre marqué se liant sélectivement et préférablement à un transporteur de la dopamine qu'à un transporteur de la sérotonine dans un ratio de 10 ou plus. Ces composés peuvent être préparés en tant que diastéréoisomères individuels ou sous forme d'un mélange de diastéréoisomères. Sont également divulguées des trousses radiopharmaceutiques permettant la préparation des composés radiopharmaceutiques marqués.

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