Dopamine transporter imaging agents

Details Dopamine transporter imaging agents Dopamine transporter imaging agents

A - Human Necessities

61

K

A61K 51/04 (2006.01)

Patent

CA 2721484

Radiopharmaceutical compounds are disclosed. A tropane compound is linked through the N atom at the 8-position to a chelating ligand capable of complexing technetium or rhenium to produce a neutral labeled complex that selectively binds to the dopamine transporter over the serotonin transporter with a ratio of or more. These compounds can be prepared as separate diastereoisomers as well as a mixture of diastereoisomers. Also disclosed are radiopharmaceutical kits for preparing the labeled radiopharmaceutical compounds.

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