C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/00 (2006.01) C12N 5/0735 (2010.01) C12N 5/079 (2010.01) C12N 5/0797 (2010.01) A61K 35/12 (2006.01) A61K 35/30 (2006.01) A61P 25/16 (2006.01) C12N 5/10 (2006.01) C12Q 1/02 (2006.01)
Patent
CA 2451486
This disclosure provides improved methods for obtaining populations of neural progenitor cells and differentiated neurons from pluripotent stem cells. The technology can be used to produce progenitors that proliferate through at least 40 doublings, while maintaining the ability to differentiate into a variety of different neural phenotypes. Cell populations have been obtained that contain a high proportion of cells staining for tyrosine hydroxylase, which is a feature of dopaminergic neurons. The neural progenitors and terminally differentiated neurons of this invention can be generated in large quantities for use in drug screening and the treatment of clinically important neurological disorders, such as Parkinson's disease.
L'invention concerne des méthodes améliorées permettant d'obtenir des populations de cellules souches neuronales et des neurones différenciées provenant de cellules souches totipotentes. On peut utiliser cette technique pour produire des progéniteurs qui prolifèrent à travers au moins 40 doublages, tandis qu'on conserve leur capacité à se différencier en une variété de phénotypes neuronaux différents. On a obtenu des populations cellulaires qui contiennent une proportion élevée de cellules se colorant en cas de tyrosine hydroxylase, ce qui est une caractéristique des neurones dopaminergiques. On peut produire les progéniteurs neuronaux et des neurones définitivement différenciées en grandes quantités, de manière à les utiliser dans le cadre du criblage de médicaments et du traitement de troubles neurologiques graves sur le plan clinique, tels que la maladie de Parkinson.
Carpenter Melissa K.
Denham Jerrod J.
Inokuma Margaret S.
Thies Scott R.
Geron Corporation
Smart & Biggar
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