Dosage forms comprising a cetp inhibitor and an hmg-coa...

Details Dosage forms comprising a cetp inhibitor and an hmg-coa... Dosage forms comprising a cetp inhibitor and an hmg-coa...

A - Human Necessities

61

K

A61K 31/4706 (2006.01) A61K 9/14 (2006.01) A61K 9/16 (2006.01) A61K 31/40 (2006.01) A61K 47/30 (2006.01) A61K 47/38 (2006.01)

Patent

CA 2508840

A dosage form comprises (1) a solid amorphous dispersion comprising a cholesteryl ester transfer protein inhibitor and a neutral or neutralized acidic polymer and (2) an HMG-CoA reductase inhibitor. The dosage form provides improved chemical stability of the HMG-CoA reductase inhibitor.

La présente invention se rapporte à une forme posologique qui renferme (1) une dispersion amorphe solide comprenant un inhibiteur de protéine de transfert d'ester de cholestéryle et un polymère acide neutralisé ou neutre et (2) un inhibiteur de HMG-CoA réductase. La forme posologique assure une stabilité chimique améliorée à l'inhibiteur de HMG-CoA réductase.

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