A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/06 (2006.01) A61K 9/00 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2690119
In various embodiments, the present invention provides methods, compositions, dosing, and administration schedules for treatment of autoimmune diseases, including systemic erythematosus (SLE), for example, comprising administering to a patient in need of such treatment a TACI-Ig fusion molecule such as atacicept. In one embodiment, the TACI-Ig fusion molecule is administered in amount sufficient to slow, suppress or inhibit proliferation-inducing functions of BLyS and APRIL, in particular the use of multiple administrations of the fusion molecule at relatively low dose over the course of the treatment. In various embodiments, the present invention provides methods, compositions, dosing, and administration schedules for treatment of autoimmune diseases, including systemic erythematosus (SLE), for example, comprising administering to a patient in need of such treatment a TACI-Ig fusion molecule such as atacicept. In one embodiment, the TACI-Ig fusion molecule is administered in amount sufficient to slow, suppress or inhibit proliferation-inducing functions of BLyS and APRIL, in particular the use of multiple administrations of the fusion molecule at relatively low dose over the course of the treatment.
L'invention concerne des procédés, des compositions, un dosage, et des programmes d'administration pour le traitement de maladies auto-immunes, y compris l'érythème systémique (SLE), par exemple, comprenant l'administration à un patient nécessitant un tel traitement d'une molécule de fusion TACI-Ig telle qu'atacicept. Selon un mode de réalisation, la molécule de fusion TACI-Ig est administrée en quantité suffisante pour ralentir, supprimer ou empêcher des fonctions de BLyS et APRIL induisant une prolifération, en particulier l'utilisation de multiples administrations de la molécule de fusion à une dose relativement faible au cours du traitement.
Busby Sharon J.
Gross Jane A.
Munafo Alain
Nestorov Ivan
Papasouliotis Orestis
Ares Trading S.a.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Zymogenetics Inc.
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