Dpp-iv resistant gip hybrid polypeptides with selectable...

C - Chemistry – Metallurgy – 07 – K

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C07K 14/575 (2006.01)

Patent

CA 2660835

The present invention relates generally to novel GIP analogs and GIP hybrid polypeptides with selectable properties, useful as agents for the treatment and prevention of metabolic diseases and disorders, for example those which can be alleviated by control plasma glucose levels, insulin levels, and/or insulin secretion, positive inotropic effects, reduction of catabolic effects, slowing of gastric emptying. Such conditions and disorders include, but are not limited to, hypertension, dyslipidemia, cardiovascular disease, eating disorders, critical care, insulin-resistance, obesity, and diabetes mellitus of any kind, including type 1, type 2, and gestational diabetes.

La présente invention concerne globalement des analogues du GIP et des polypeptides hybrides du GIP possédant des propriétés sélectives, utiles comme agents destinés au traitement et à la prévention de troubles et de maladies métaboliques, tels que ceux pouvant être soulagés par régulation de la glycémie plasmatique, des taux d'insuline, et/ou de la sécrétion de l'insuline, avec des effets inotropes positifs, une réduction des effets cataboliques et un ralentissement de la vidange gastrique. Les troubles et les maladies concernés comprennent, sans en exclure d'autre, l'hypertension, la dyslipidémie, la maladie cardio-vasculaire, les troubles alimentaires, les soins intensifs, la résistance à l'insuline, l'obésité et le diabète sucré de n'importe quel type, y compris de type 1, de type 2, et de type gestationnel.

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