A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/14 (2006.01) A61K 31/4422 (2006.01)
Patent
CA 2661683
The present invention is directed to pharmaceutical compositions and dosage forms comprising TPR beads, wherein said TPR beads comprise a solid dispersion of at least one active pharmaceutical ingredient in at least one solubility-enhancing polymer, and a TPR coating comprising a water insoluble polymer and an enteric polymer, wherein the active pharmaceutical ingredient comprises a weakly basic active pharmaceutical ingredient having a solubility of not more than 100 µg/mL at pH 6.8.
La présente invention concerne des compositions pharmaceutiques et des formes de dosage comprenant des billes TPR, lesquelles billes TPR renferment une dispersion solide d'au moins un principe pharmaceutique actif dans au moins un polymère promoteur de solubilité, et un revêtement TPR incluant un polymère insoluble dans l'eau et un polymère entérique, le principe pharmaceutique actif comportant un principe pharmaceutique actif faiblement basique dont la solubilité est égale ou inférieure supérieure à 100 µg/mL à un pH de 6,8.
Boltri Luigi
Colombo Italo
Flabiani Flavio
Lai Jin-Wang
Mapelli Luigi
Aptalis Pharmatech Inc.
Deeth Williams Wall Llp
Eurand Inc
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